Tag Archives: SAPHO

Jaw swelling and pain: a biography of CRMO

On Tuesday, I challenged readers to figure out the cause of a girl’s jaw swelling and pain.  Over 130 people read the story, and seven people submitted their responses on this website.  You can read the original case here.  Read below for the complete case, in addition to comments about the correct diagnosis. Continue reading Jaw swelling and pain: a biography of CRMO

What the heck are autoinflammatory diseases?

Autoinflammatory diseases are a relatively new category of illnesses caused by disorders of one arm of the immune system. Many of these diseases are characterized by recurrent fevers, rash, chest and abdominal pain, and evidence of systemic inflammation on blood tests; these manifestations often mimic infectious or other illnesses, and it may take several years for the diagnosis to be made.

Most autoinflammatory diseases are genetic (inherited), start in childhood, and persist throughout adult life. These diseases are often present in several members of a family. Other autoinflammatory diseases appear to be acquired, perhaps due to the interplay of genetic and environmental factors, and can present at any time during childhood or adulthood.

The list of autoinflammatory diseases continues to grow every month.  Here is a list of the autoinflammatory diseases as they stand so far: