(R)evolutionary Rheumatology

I spent most of my senior year in college in the basement of the science building, in a room the size of a closet, watching (and videotaping) fish having sex. I was studying pipefish, a relative of the seahorse in which the males get pregnant. I was interested in learning how this unusual quirk of evolution affected the sex roles of the fish, asking questions such as: which sex is more promiscuous, bigger, and more aggressive? Evolution was at the heart of my biology major, and its existence was palpable in every biology class I took—from Genetics sophomore year to a senior seminar on Ecology. It was clear during my undergraduate education that “nothing in biology makes sense except in the light of evolution.” Continue reading (R)evolutionary Rheumatology

Mastering the Inpatient Consult Service

Every few months I have the pleasure of teaming up with one of my fellows (and often a resident, and sometimes a medical student), to evaluate hospitalized patients with known or suspected rheumatic diseases as part of the inpatient consult service. This is quite a change from my typical day as a rheumatologist, where I see patients in an outpatient clinic.

On occasion, patients with known rheumatic diseases land in the hospital—the patient with lupus and worsening kidney disease, the patient with gout and a severe flare, the patient with vasculitis experiencing a relapse. At the same time, many patients are admitted for workup of unexplained symptoms—joint pain, fevers, rash—or develop these while being treated other conditions. For these patients, we are asked to evaluate for the presence of rheumatic diseases.

Having just finished covering the inpatient rheumatology consult service, I am reflecting on my week and have identified 15 factors that help you achieve a successful week. Continue reading Mastering the Inpatient Consult Service

Predicting Colchicine Response in Patients with Undefined Autoinflammatory Diseases

 

Background/Purpose:

Autoinflammatory diseases (AIDs) are a rare group of illnesses characterized by unprovoked episodes of fever and systemic inflammation.  An understanding of their pathophysiology has led to the development of effective treatment guidelines. Unfortunately, many patients with recurrent fevers have symptoms that do not match any of the known AIDs. There is an unmet need to provide effective treatment to these patients with undefined AIDs (uAIDs). Colchicine, a treatment for patients with familial Mediterranean fever, is sometimes used to treat patients with uAIDs. We examined the efficacy of colchicine in patients with uAIDs and identified clinical factors that predicted a good colchicine response.

Continue reading Predicting Colchicine Response in Patients with Undefined Autoinflammatory Diseases

Feverprints: A Crowdsourcing Study of Temperature in Health and Disease

Background/Purpose:

Despite the widespread use of temperature measurement in healthcare, our ability to use temperature data to diagnose patients is limited; it remains challenging to distinguish fevers of rheumatic illnesses from those of infectious or malignant conditions. We created Feverprints, a crowdsourcing research app to understand temperature variation between individuals, determine unique fever patterns (“feverprints”) for a variety of illnesses, and examine how antipyretics affect disease course. We report preliminary data from temperatures collected during the first 9 months of the study.

Continue reading Feverprints: A Crowdsourcing Study of Temperature in Health and Disease

The Feverprints App: Crowdsourcing Technology to Study Temperatures in Health and Disease

Purpose

Fever is a cardinal feature of autoinflammatory diseases and complicates the course for other rheumatic illnesses. Despite the widespread use of temperature measurement in healthcare, our ability to use temperature for diagnosis is limited, and distinguishing fevers of rheumatic illnesses from those of infectious or malignant conditions remains challenging. We created Feverprints, a crowdsourcing research app to understand temperature variation between individuals, determine unique fever patterns (“feverprints”) for a variety of illnesses, and examine how antipyretics affect disease course. We report preliminary data from temperatures and symptoms collected during the first 9 months of the study.

Continue reading The Feverprints App: Crowdsourcing Technology to Study Temperatures in Health and Disease

Uncovering the mysteries of autoinflammatory diseases and other rheumatic illnesses.

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