All posts by Jonathan Hausmann

I am a pediatric and adult rheumatologist at Boston Children’s Hospital and Beth Israel Deaconess Medical Center. I have an interest in autoinflammatory diseases, medical education, and the role of social media and technology in healthcare.

Predicting Colchicine Response in Patients with Undefined Autoinflammatory Diseases

 

Background/Purpose:

Autoinflammatory diseases (AIDs) are a rare group of illnesses characterized by unprovoked episodes of fever and systemic inflammation.  An understanding of their pathophysiology has led to the development of effective treatment guidelines. Unfortunately, many patients with recurrent fevers have symptoms that do not match any of the known AIDs. There is an unmet need to provide effective treatment to these patients with undefined AIDs (uAIDs). Colchicine, a treatment for patients with familial Mediterranean fever, is sometimes used to treat patients with uAIDs. We examined the efficacy of colchicine in patients with uAIDs and identified clinical factors that predicted a good colchicine response.

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Feverprints: A Crowdsourcing Study of Temperature in Health and Disease

Background/Purpose:

Despite the widespread use of temperature measurement in healthcare, our ability to use temperature data to diagnose patients is limited; it remains challenging to distinguish fevers of rheumatic illnesses from those of infectious or malignant conditions. We created Feverprints, a crowdsourcing research app to understand temperature variation between individuals, determine unique fever patterns (“feverprints”) for a variety of illnesses, and examine how antipyretics affect disease course. We report preliminary data from temperatures collected during the first 9 months of the study.

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The Feverprints App: Crowdsourcing Technology to Study Temperatures in Health and Disease

Purpose

Fever is a cardinal feature of autoinflammatory diseases and complicates the course for other rheumatic illnesses. Despite the widespread use of temperature measurement in healthcare, our ability to use temperature for diagnosis is limited, and distinguishing fevers of rheumatic illnesses from those of infectious or malignant conditions remains challenging. We created Feverprints, a crowdsourcing research app to understand temperature variation between individuals, determine unique fever patterns (“feverprints”) for a variety of illnesses, and examine how antipyretics affect disease course. We report preliminary data from temperatures and symptoms collected during the first 9 months of the study.

Continue reading The Feverprints App: Crowdsourcing Technology to Study Temperatures in Health and Disease

Colchicine efficacy for undefined autoinflammatory diseases

Purpose

Autoinflammatory diseases (AIDs) are a rare group of illnesses characterized by unprovoked episodes of fever and systemic inflammation.  Patients with defined AIDs benefit from evidence-based treatment guidelines1. Unfortunately, many patients with AIDs do not have a genetic diagnosis and their symptoms do not match any of the known AIDs. There is an unmet need to provide effective treatment to these patients with undefined AIDs (uAIDs). We examined the efficacy of colchicine in patients with uAIDs and identified patient characteristics and clinical factors that predicted a good colchicine response.

Continue reading Colchicine efficacy for undefined autoinflammatory diseases

Your headaches…are they autoinflammatory?

She had headaches for many years.  She visited multiple doctors, including her primary care physician, a neurologist, a pain clinic, and even a headache specialist, but she was unable to find an effective treatment.   Over time she developed additional symptoms, including unexplained rashes and abdominal pain. When a close family member was diagnosed with an autoinflammatory disease, she was referred to my clinic to see if she, too, had one of these rare illnesses. Continue reading Your headaches…are they autoinflammatory?